| Rank | Name | Year | School | Meet | Time |
| 1 | Malyka Abramson | 2013 | Avon | Franklin Inv. | 17:56.5 |
| 2 | Mackenzie Caldwell | 2013 | Columbus North | Franklin Inv. | 18:08 |
| 3 | Brenner Hanna | 2020 | Greensburg | Regional | 18:20 |
| 4 | Allie Dalton | 2015 | Greenwood Christian | Franklin Inv. | 18:21 |
| 5 | Lauren Klem | 2020 | Franklin | Johnson Co. | 18:25 |
| 6 | Erin Sullivan | 2016 | Southport | Sectional | 18:33 |
| 7 | Chanli Mundy | 2011 | Terre Haute North | Franklin Inv. | 18:43 |
| 8 | Tori Schoettmer | 2012 | Center Grove | Johnson Co. | 18:47 |
| 9 | Kieran Casey | 2012 | Perry Meridian | Franklin Inv. | 18:49 |
| Samantha Woodford | 2014 | Plainfield | Mid-State Conf. | 18:49 |
| 11 | Rachael Sollman | 2011 | Columbus North | Franklin Inv. | 18:55 |
| 12 | Jordan Timmons | 2012 | Center Grove | Johnson Co. | 18:57 |
| 13 | Lilly Brunsman | 2020 | Center Grove | Regional | 18:59 |
| 14 | Sierra Lax | 2013 | Columbus North | Franklin Inv. | 19:00 |
| 15 | Lily Pinckley | 2019 | Batesville | Regional | 19:02 |
| 16 | Courtney Kerr | 2013 | Avon | Franklin Inv. | 19:07 |
| Madison Vauters | 2014 | Mooresville | Mid-State Conf. | 19:07 |
| 18 | Bella Hodges | 2020 | Center Grove | Johnson Co. | 19:08 |
| 19 | Lexie Green | 2016 | Southport | Sectional | 19:10 |
| 20 | Erin Shuffett | 2011 | Columbus North | Sectional | 19:11 |
| Rank | Name | Year | School | Meet | Time |
| 1 | Luke Brahm | 2011 | Ben Davis | Franklin Inv. | 15:27.82 |
| 2 | Andrew Diehn | 2011 | Columbus North | Franklin Inv. | 15:33 |
| 3 | Tyeson Mundy | 2011 | Terre Haute North | Franklin Inv. | 15:34 |
| 4 | Zack Snider | 2013 | Brebeuf | Franklin Inv. | 15:35 |
| 5 | David Dalton | 2013 | Greenwood | Franklin Inv. | 15:37 |
| 6 | Jace Lowry | 2010 | Martinsville | Mid-State Conf. | 15:43 |
| Will Jefferson | 2019 | Whiteland | Johnson Co. | 15:43 |
| 8 | Clayton Bowie | 2013 | Southport | Sectional | 15:49 |
| 9 | Michael Passmore | 2012 | Mooresville | Franklin Inv. | 15:50 |
| 10 | Isaiah White | 2013 | Perry Meridian | Franklin Inv. | 15:52 |
| 11 | Dalton Kane | 2018 | Plainfield | Mid-State Conf. | 15:53 |
| 12 | Michael Sublette | 2011 | Columbus North | Franklin Inv. | 15:54 |
| Griffin Miller | 2014 | Center Grove | Sectional | 15:54 |
| 14 | Chris Kelsey | 2011 | Columbus North | Sectional | 15:55 |
| 15 | Wyatt McCullough | 2019 | Franklin | Johnson Co. | 15:57 |
| 16 | Archit Malik | 2019 | Center Grove | Johnson Co. | 15:58 |
| Ty Garrett | 2019 | Center Grove | Sectional | 15:58 |
| Jacob James | 2019 | Waldron | Regional | 15:58 |
| 19 | Andrew Bixler | 2018 | Franklin | Mid-State Conf. | 16:00 |
| 20 | Kaden Eaton | 2013 | Columbus North | Franklin Inv. | 16:02 |