| Rank | Team | Time | Year |
| 1 | Kelsay, Simmons, Beavins, Doublin | 49.38 | 2018 |
| 2 | Stringer, Briggs, McClure, Long | 49.82 | 1997 |
| 3 | Stone, Thompson, Chiarotti, Golden | 50.00 | 1989 |
| 4 | Hoy, Woods, Novak, Simmons | 50.84 | 2017 |
| 5 | Stone, Teike, Chairotti, Eades | 51.10 | 1988 |
| 6 | McWhorter, Stock, Burgess, Bullington | 51.30 | 2003 |
| 7 | Stringer, McClure, Briggs, White | 51.60 | 1998 |
| 8 | Pruitt, Baker, Logan, Golden | 51.69 | 1984 |
| 9 | Humes, Olsen, Baker, Linville | 51.70 | 1982 |
| Long, Reese, McClure, Cummings | 51.70 | 1996 | |
| 11 | Morgan Sandrock, Sami Frazier, Hailey Stewart, Ava Lenkey | 51.84 | 2023 |
| 12 | Aubrey Runyon, Ava Lenkey, Sabina Garcia, Olivia Nicoloff | 51.92 | 2022 |
| 13 | Emry, Clarkston, Briggs, McWhorter | 52.04 | 2000 |
| 14 | Blotch, McClure, Clarkston, Long | 52.10 | 1995 |
| 15 | Cearing, Shaul, Burgess, Bullington | 52.14 | 2004 |
| 16 | Stone, Teike, Chairotti, Eades | 52.15 | 1987 |
| 17 | Richter, Shaul, Bullington, Burgess | 52.28 | 2006 |
| 18 | Cearing, Shaul, Burgess, Bullington | 52.31 | 2005 |
| 19 | Hoy, Woods, Novak, Simmons | 52.38 | 2016 |
| 20 | No recorded names | 52.40 | 1986 |
| 21 | Baker, Shatto, Logan, Eades | 52.48 | 1985 |
| 22 | Richter, Allee, D. Smith, Hamner | 52.53 | 2009 |
| 23 | M. Hoy, C. Sandrock, E. Beavins, K. Doublin | 52.58 | 2015 |
| 24 | Repp, Lucas, Records, Hearin | 52.60 | 1980 |
| 25 | O. Nicoloff, C. Kelsay, L. Clark, M. Doublin | 52.67 | 2019 |
| Rank | Team | Time | Year |
| 1 | Scott, Pfifer, Ballay, Murr | 43.26 | 2011 |
| 2 | Hall, Shephard, Packer, Jordan | 43.50 | 1989 |
| 3 | Ethan Elsner, Elijah Smith, Aidan Jefry, Dylan Beverly | 43.77 | 2023 |
| 4 | Hunter, McCarty, Martin, Shephard | 43.90 | 1992 |
| Giddens, Clark, Warner, B. Murr | 43.90 | 2010 | |
| 6 | Jordan, Packer, Shephard, Hall | 44.01 | 1988 |
| 7 | N. Belser, C. Thompson, J. Weinhorst, S. Whittenbarger | 44:04 | 1998 |
| 8 | Price, Yaden, Epperson, Hunter | 44.22 | 1993 |
| 9 | Jones, McCann, Harris, Murr | 44.23 | 2017 |
| 10 | M. Sever, Richards, Mosburg, Hunter | 44.68 | 1995 |
| 11 | Kocher, Thompson, Wienhorst, Whittenbarger | 44.75 | 1997 |
| 12 | J. Smith, B. Murr, Makransky, Moran | 44.80 | 2009 |
| 13 | M. Nickleson, A. Freese-Gastil, A. Jefry, G. Hueston | 44.85 | 2022 |
| 14 | Gardner, Madison, Nibarger, J. Williams | 45.10 | 2006 |
| 15 | B. Epperson, E. Richards, B. Yaden, M. Cowden | 45.10 | 1994 |
| 16 | J. Cox, M. Chadbourne, A. Shepherd, Z. Dowell | 45.2 | 2014 |
| 17 | A. Loos, C. Mills, K. Hamblin, R. McCann | 45.27 | 2018 |
| 18 | D. Utterback, T. Reed, J. Cox, T. Murr | 45.32 | 2015 |
| 19 | Baumgardner, Hamner, Turner, Wagner | 45.36 | 2002 |
| 20 | Deckard, Whittenbarger, Stevenson, Huddleston | 45.33 | 1999 |
| 21 | Nibarger, Montalvo, Noblitt, Madison | 45.40 | 2005 |
| 22 | Z. Dowell, A. Ballay, A. Shepherd, J. Cox | 45.42 | 2013 |
| 23 | Hamner, Montalvo, Walls, Young | 45.47 | 2003 |
| 24 | Turner, Green, Svenback, White | 45.50 | 1981 |
| 25 | Giddens, Houston, Leonard, A. Williams | 45.50 | 2008 |